Top 8 reasons for the failure of IVF | Why did my IVF fail?

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reasons for the failure of IVF

IVF, or InVitro Fertilisation, is one of the most prominent procedures that helps couples all over the world achieve their dream of having a baby. The average success rate of this procedure is fifty percent, which means that half of the population that takes up this may not be blessed with a child. There are many reasons why IVF procedures become a failure. 

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The blog gives you an insight into the major reasons for the failure of IVF:

Embryo implantation failure

The failure to implant embryos into the uterus lining is one of the major reasons for failure of IVF. The doctors are yet to find out the exact reasons for the unsuccessful attempt. The misfiring of the attempt can happen due to two reasons; either due to the problem of the embryo or because of the uterus. It is still difficult to pinpoint the exact cause of the problem. Unhealthy embryos do not have a chance of survival beyond five days. The reason for weak and unhealthy embryos is not yet figured out and is termed a “black box” question in the field of IVF. To improve the chances of successful embryo implantation, the woman can take up PGS testing with IVF, which can help infertility doctors select healthy embryos for implantation.

Quality of Eggs

Embryo implantation is 50% successful for women under 35 years old and only 12% for women over 40. If the woman has a healthy uterus but if the quality of the female egg is poor, then it is fitting that you choose IVF with donor eggs. If the quality of eggs is the key reason for failed IVF, transferring them to a surrogate will also result in failure. The conceiving issues for older women are mainly due to low-quality eggs and not because of the uterus. 

Female age and Ovarian response

The age, the health of the uterus, and how it responds to IVF medications are of prime importance when it comes to the successful procedure of IVF. Normally, an ovary releases an egg every month, and this decreases when the woman is in her mid-30s. Before starting the IVF cycle, medications are induced in the ovary to produce more eggs. If the woman is already facing a decline in the number of eggs or a low FSH level, then the chances that the IVF medications are being used are less. Fertility tests for women can help determine their fertility levels and help the doctor decide on the most appropriate treatment.

Quality of Sperm

The sperm has to be motile, in sufficient quantity and of good quality. The term “motility of the sperm” refers to the tail of the sperm being able to propel itself into the tract of the female egg. The eggs and sperm have special receptors on their surface, which will enhance their interaction. Once it happens, there are enzymes released from the sperm that break the outer membrane of the egg to produce a hole and then fuse with the egg. The quality of the sperm can usually be analysed before the IVF procedure through semen analysis. If they find issues, then the couple can adopt ICSI or IVF sperm donors. 

Genetic and Chromosomal Causes

Chromosomal abnormalities are the prime reasons for the failure of IVF procedure. The rate of such abnormalities in human eggs started to increase after the mid-’30s. IVF procedure in older women: women over the age of 40 are more likely to have lower quality eggs that are chromosomally abnormal, resulting in a lower success rate for the IVF procedure. Research also suggests that sperm carry far more abnormalities than the female egg, which can also be one of the reasons for the failure of IVF procedure.

IVF lab factors

IVF laboratories are tightly controlled environments, which are similar to that of a female reproductive tract for the sperm, eggs, and embryos. There is tight control over the oxygen, carbon dioxide, PH levels and other factors. Even a slight change in the above levels can change the environment that the embryos usually experience and can lead to their death, which will result in the failure of conception in that cycle. It is important to choose the best IVF centre in Kerala for your treatment.

Problems with egg retrieval and embryo transfer

The surgical procedure of egg retrieval and embryo transfer itself, has a major hand in deciding the success of the IVF procedure. The retrieval of fewer eggs or no eggs itself can cause the failure of the entire process. The embryo transferred should be kept in the right location for the successful completion of the IVF cycle. An unsuccessful attempt at doing so can result in failure and bring down the chances of a successful conception of pregnancy. 

Embryo Selection

The embryos that are transferred to the uterus are selected by the embryologist. The selection of chromosomally normal from chromosomally abnormal embryos is still a severely limited process. The experience of the embryologist and their techniques have to be severely depended upon for the success of the IVF procedure.

KJK hospital has been successful in rendering services for infertility for the past 21 years. KJK has been able to resolve the fertility challenges experienced by couples all over the world. KJK hospital is quick to adapt to new-age technologies, and it is only because of their indebted assistance that they have become the one-stop solution for best infertility treatments in Kerala

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